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Showing 1–2 of 2 results
Advanced filters: Author: Vincent Moutardier Clear advanced filters

  • Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.

    • Orianne Olivares
    • Jared R. Mayers
    • Sophie Vasseur
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.

    • Gwen Lomberk
    • Yuna Blum
    • Raul Urrutia
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10