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Showing 1–5 of 5 results
Advanced filters: Author: Vincent S. Tagliabracci Clear advanced filters
  • Reconstitution of the SARS-CoV-2 RNA 5′ cap reveals the unconventional mechanism by which SARS-CoV-2 caps its RNA genome, providing a new target in the development of antiviral agents to treat COVID-19.

    • Gina J. Park
    • Adam Osinski
    • Vincent S. Tagliabracci
    ResearchOpen Access
    Nature
    Volume: 609, P: 793-800
  • For homeostatic plasticity, neuronal circuits rely on poorly understood retrograde signals. Here, the authors identify a visual activity-dependent feedback loop mediated by the secreted Allnighter pseudokinase with effects on brain-wide proteostasis and sleep.

    • Shashank Shekhar
    • Andrew T. Moehlman
    • Helmut Krämer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression.

    • Ryan J. Golden
    • Beibei Chen
    • Joshua T. Mendell
    Research
    Nature
    Volume: 542, P: 197-202
  • Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the function and regulation of this kinase family.

    • Hui Zhang
    • Qinyu Zhu
    • Junyu Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12