The process by which mammalian L1 retrotransposons move around the genome is not entirely clear. Now structural work on L1ORF1 protein, an RNA-binding protein essential for retrotransposition, reveals a trimeric organization and considerable interdomain flexibility. The latter is shown by mutagenesis to be critical for retrotransposition.
- Elena Khazina
- Vincent Truffault
- Oliver Weichenrieder
