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Showing 1–5 of 5 results
Advanced filters: Author: Vincent Villeret Clear advanced filters

  • The Mediator complex subunit MED23 contributes to transcriptional activation by the phosphorylated transcription factor Elk-1, in response to Ras-MAPK signalling. Here, the authors determine a cryo-EM structure of human MED23 with the phosphorylated activation domain of Elk-1 providing insights into the Mediator subunit-transcription factor interface.

    • Didier Monté
    • Zoé Lens
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The fundamental processes of protein insertion and translocation at the outer membrane are mediated by Omp85 proteins. Here the authors report structures of the translocase FhaC, showing that the critical L6 loop adopts a conformation similar to that of related insertases; establishing a common structural basis for Omp85 function.

    • Timm Maier
    • Bernard Clantin
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.

    • Didier Monté
    • Bernard Clantin
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Haemophilus influenzae requires haem, and acquires it from host haemoproteins including haemopexin. Here, the authors examine the haem transport system consisting of HxuA, HxuB and HxuC via the structures of HxuA in complex with haemopexin.

    • Silvia Zambolin
    • Bernard Clantin
    • Philippe Delepelaire
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Several tuberculosis drugs are prodrugs that have to be enzymatically activated during metabolism. Ethionamide is such a drug and is activated by the monooxygenase EthA. EthA is itself regulated by the transcriptional repressor EthR. Here Alain Baulard and his colleagues have designed inhibitors of EthR that boost the antimycobacterial efficacy of ethionamide both in vitro and in vivo. Current therapy with ethionamide requires the use of high doses, often eliciting side effects. Its combination with the EthR repressor should allow lower doses to be used.

    • Nicolas Willand
    • Bertrand Dirié
    • Alain R Baulard
    Research
    Nature Medicine
    Volume: 15, P: 537-544