Many patients with chronic constipation have a poor quality of life and are dissatisfied with laxative treatment. Findings from a multicenter, randomized, placebo-controlled, phase III study have demonstrated the beneficial effects of the 5-hydroxytryptamine 4 receptor agonist, prucalopride, for chronic constipation and associated symptoms. This drug represents the newest addition to the medical armamentarium for this disorder.
- Gabrio Bassotti
- Vincenzo Villanacci
