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Showing 1–5 of 5 results
Advanced filters: Author: Viola Nähse Clear advanced filters

  • The endoplasmic reticulum protein DFCP1 is found on omegasomes implicated in autophagosome biogenesis, but its function has remained unknown. Here, Nähse et al. show that DFCP1 is an ATPase that mediates selective autophagy by promoting constriction of large omegasomes.

    • Viola Nähse
    • Camilla Raiborg
    • Harald Stenmark
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.

    • Olivier Brison
    • Sami El-Hilali
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Analysis of the relationships between transcription, replication, and stability of large genes associated with common fragile sites suggests that high transcription levels alleviate genome instability by altering replication timing and allowing cells to complete replication before mitosis.

    • Marion Blin
    • Benoît Le Tallec
    • Michelle Debatisse
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 58-66

  • Intraluminal vesicles are formed by the endosomal sorting complex required for transport (ESCRT) machinery. Here, the authors unravel the timing of vesicle budding, and that endosomal clathrin regulates concerted recruitment of ESCRT subcomplexes, required for efficient membrane remodeling.

    • Eva Maria Wenzel
    • Sebastian Wolfgang Schultz
    • Camilla Raiborg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response and transcription-associated replication stress. These findings suggest a FANCD2-mediated coordination of nuclear and mitochondrial responses to stress.

    • Philippe Fernandes
    • Benoit Miotto
    • Valeria Naim
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16