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Showing 1–3 of 3 results
Advanced filters: Author: Violetta Steeples Clear advanced filters

  • Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.

    • Marco L. Hennrich
    • Natalie Romanov
    • Anthony D. Ho
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.

    • Arash Yavari
    • Mohamed Bellahcene
    • Houman Ashrafian
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19