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Showing 1–3 of 3 results
Advanced filters: Author: Virginia Vega-Warner Clear advanced filters

  • Lassé et al. show that genes involved in kidney organoid proteomic response to TNFα segregate a subset of individuals with poor outcomes in proteinuric kidney disease, demonstrating the relevance of kidney organoid modeling to human kidney disease.

    • Moritz Lassé
    • Jamal El Saghir
    • Markus M. Rinschen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Steroid-sensitive nephrotic syndrome (SRNS) can cause CKD and necessitate kidney transplant. Here the authors identify FAT1 mutations by homozygosity mapping and whole-exome sequencing in families with SRNS and provide functional mouse and zebrafish evidence that FAT1 is required for normal glomerular and tubular function and that FAT1 mutations can cause SRNS.

    • Heon Yung Gee
    • Carolin E. Sadowski
    • Friedhelm Hildebrandt
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11