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Showing 1–5 of 5 results
Advanced filters: Author: Virginie Tardif Clear advanced filters
  • Modulating pro-inflammatory immune cell kinetics after myocardial infarction is a critical step to prevent heart dysfunction. In this study, the authors show that Ezh2 pharmacological inhibition, acting as an epigenetic checkpoint in monocytes and macrophages, prevents myocardial infarction-induced cardiac dysfunction.

    • Julie Rondeaux
    • Déborah Groussard
    • Sylvain Fraineau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.

    • Margaret H. O’Connor
    • Roshell Muir
    • Elias K. Haddad
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13
  • Multiple sclerosis is associated with a deficiency in generation of mature oligodendroctyes; an image-based screen for oligodendrocyte differentiation inducers identified the compound benztropine, which enhances remyelination acting through muscarinic receptors and decreases clinical severity in a multiple sclerosis model system.

    • Vishal A. Deshmukh
    • Virginie Tardif
    • Luke L. Lairson
    Research
    Nature
    Volume: 502, P: 327-332