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Showing 1–2 of 2 results
Advanced filters: Author: Virve Cavallucci Clear advanced filters

  • Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.

    • Annalisa Nobili
    • Emanuele Claudio Latagliata
    • Marcello D’Amelio
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • In a mouse model of Alzheimer's disease, the authors find that early loss of AMPA receptors at synapses at onset of cognitive dysfunction is a result of activation of the phosphatase calcineurin by caspase-3. Inhibition of caspase activity rescued both synapse density and fear memory in this model.

    • Marcello D'Amelio
    • Virve Cavallucci
    • Francesco Cecconi
    Research
    Nature Neuroscience
    Volume: 14, P: 69-76