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Showing 1–2 of 2 results
Advanced filters: Author: Viviane Reber Clear advanced filters

  • Here, the authors show that physiological alpha-synuclein supports mitochondrial ATP homeostasis via interactions with ATP synthase and AK2, whereas its disease-linked mutants, truncated forms, and aggregates lose these interactions.

    • Tetiana Serdiuk
    • Yanick Fleischmann
    • Roland Riek
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.

    • Dominic D. G. Owens
    • Matthew E. R. Maitland
    • Cheryl H. Arrowsmith
    Research
    Nature Chemical Biology
    Volume: 20, P: 1164-1175