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Showing 1–2 of 2 results
Advanced filters: Author: Vladimir B Teif Clear advanced filters

  • The ability to predict epigenetic regulation is an important challenge in biology. Here the authors describe heterochromatin nanodomains (HNDs) and compare four different types of H3K9me2/3-marked HNDs in mouse embryonic stem cells. They further develop a computational framework to predict genome-wide HND maps from DNA sequence and protein concentrations, at single-nucleotide resolution.

    • Graeme J. Thorn
    • Christopher T. Clarkson
    • Vladimir B. Teif
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Tissue- and disease-specific features of nucleosome positioning have recently been reported. A new study set out to identify features of nucleosome positioning at functional genomic elements during lineage commitment from mouse embryonic stem cells to neural progenitors and embryonic fibroblasts. The results reveal regulatory mechanisms of cell differentiation that involve nucleosome positioning.

    • Vladimir B Teif
    • Yevhen Vainshtein
    • Karsten Rippe
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1185-1192