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DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a variety of acute or chronic recordings from humans, nonhuman primates and mice.

Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8⁺ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8⁺ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

A 2.5-billion-year record of oxygen isotopes in sedimentary sulfate reveals the transitional oxygenation of the Earth’s surface and provides constraints on the dynamic, lengthy co-oxygenation of Earth’s atmosphere and oceans.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

The hunt for a quantum spin liquid has involved many different material families and models. Now, Zn-barlowite has been found to have similar behaviour to another candidate material, herbertsmithite, hinting there may be universal physical behaviour.

Dendritic cells (DCs) initiate distinct arms of immunity in response to different classes of pathogens. Here Gringhuis et al. show that DCs produce IL-27 upon sensing fucose-containing pathogen ligands via DC-SIGN, promoting follicular T helper cell differentiation and antibody production.

Sivanandan, Leitmann, and colleagues present the CellPaint-POSH platform, which combines pooled CRISPR screening with Cell Painting. Using self-supervised deep learning on cell images, the method enables discovery of gene function and biological networks.

Here, using pre-HIV-infection and non-HIV samples in a multi-modal study of microbiomes and metabolomes, the authors develop a taxon-specific measure of DISruption in COrrelations (DISCO) revealing system-wide dysbiosis preceding HIV-1 infection in men who have sex with men.

Although genome editing has transformed plant research, delivering editing reagents remains challenging. This study reports the use of viral vectors to deliver engineered eTnpBc, achieving high levels of somatic and heritable editing in plants.

The contribution of vibrations to the stability of high-entropy ceramics is still controversial. Here the authors computationally integrate disorder parameterization, phonon modelling, and thermodynamic characterization to investigate the role of vibrations to the stability of high-entropy carbides.

Proapoptotic signals trigger the transition of cIAP1 from an autoinhibited monomeric form to an activated dimer. NMR and time-resolved SAXS analyses reveal the conformational dynamics of the cIAP1 monomer that facilitates rapid and irreversible activation.

Recently, frustrated quantum magnets have attracted interest for magnetocaloric applications. Here, using numerical calculations, the authors find a pronounced demagnetization cooling effect in the Kitaev magnets, ascribed to fractionalized topological excitations in the Kitaev quantum spin liquid regime.

Microwave observations of Jupiter’s moon Europa reveal subsurface properties of the ice shell covering a purported global ocean. The shell is 29 ± 10 km thick, with fractures or pores a few centimetres across that extend hundreds of metres deep.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

The polar chiral texture of the vortex or skyrmion structure in ferroelectric oxide PbTiO₃/SrTiO₃ superlattice attracts attention. Here, the authors report a theoretical framework to probe emergent chirality of electrical polarization textures.

The authors report observations of a dense and inhomogeneous ring at a surprisingly large distance from the trans-Neptunian body Quaoar.

In decision-making, choice stochasticity can arise at multiple stages in the brain. Here, the authors show that noise arising early and late relative to a nonlinear neural computation leads to opposing contextual effects on choice accuracy.

NiPS₃ is a van der Waals antiferromagnetic semiconductor where the exciton formation is strongly influenced by the magnetic ordering. Previous studies have been limited to magneto-optical approaches, but here, Lebedev, Gish and coauthors succeed in making field effect transistors that operate below the Néel temperature and observe an ultranarrow electroluminescence with a high degree of linear polarization.

Biexcitons play an important role in determining the optical properties of transition metal dichalcogenide monolayers, but their precise structure is poorly understood. Using a combination of ultrafast spectroscopy and theory, the origin of their fine structure is revealed.

Kondo materials exhibit extremely rich physics, from unconventional superconductivity to topological phases. Unfortunately, for a real material, direct solution of the Kondo lattice is practically impossible. Here, Simeth et al. present a tractable approach to this problem, showing how a multi-orbital periodic Anderson model can be reduced to a Kondo lattice model, and be applied to relevant materials and quantitatively validated with neutron spectroscopy.

Interesting non-Hermitian quantum dynamics can be accessed in analogue quantum simulators consisting of Hermitian bosonic systems with squeezing and antisqueezing terms. Here, the authors use a coplanar waveguide resonator connected to a SQUID to simulate the bosonic version of the Kitaev chain.

In this study, the capabilities of fragment-based Grand Canonical Nonequilibrium Candidate Monte Carlo (GCNCMC) to uncover experimentally validated, occluded fragment binding sites is demonstrated. The method also accurately samples multiple binding modes and calculates binding affinities without any prior structural knowledge.

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Heavy-atom molecules can possess complicated electronic structures due to pronounced electron correlation and relativistic effects. Here, the authors describe electronic states of RaF in detail by combining accurate spectroscopy and theory approaches.

This protocol describes the synthesis, purification and assembly of stable branched 4-way junction (4WJ) RNA nanoparticles conjugated with multiple hydrophobic chemotherapeutic drug molecules to target specific tumors with minimal side effects.

scTranslator is a large-scale generative model that translates single-cell transcriptomic data to proteomic data and can assess the impact of gene perturbation on protein levels.

Deconfined quantum phase transitions go beyond traditional paradigms. Here the authors reveal an unconventional dual asymmetric Kibble-Zurek scaling in the critical dynamics near the deconfined multicritical point with multiple length and time scales.

Intelectin-2 defends mucosal interfaces by crosslinking mucus and blocking microbial growth. This study reveals that mouse and human intelectin-2 recognizes galactose-rich glycans to bind and target diverse bacteria—uncovering a potent, dual-action lectin that shapes host–microbe balance.

Laser cooling is a powerful technique that enables precision measurements and quantum control, yet its implementation in molecules remains challenging due to their complex structures. Here, the authors apply 2D transverse laser cooling to a focused beam of cold barium monofluoride (138Ba19F) molecules to significantly increase beam brightness.

Lactation allows vertical microbiome transmission from the parent to the offspring in mammals. Here, the authors create a mathematical model to argue that uniparental transmission prevents the invasion of deleterious microbes and suggest that this may generate selection against male lactation.

In this study, the authors develop a mathematical modelling framework to estimate the impacts of non-pharmaceutical interventions and vaccination on COVID-19 incidence. The model accounts for changes in SARS-CoV-2 variant and population immunity, and here they use it to investigate epidemic dynamics in French Polynesia.

The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment resistance.

Radial growth in the roots of Arabidopsis, which is mediated by gene expression activated by the mobile PEAR1 and PEAR2 transcription factors, is initiated around protophloem-sieve-element cell files of procambial tissue.

The authors report that an AS03-adjuvanted chimeric hemagglutinin-based influenza vaccine induces persistent stalk-specific serum antibody and bone marrow plasma cell responses in nonhuman primates, offering promise for broader and durable flu protection.

Waning immunity and the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness and required vaccine updates. Here, the authors assess how different priming regimens affect the immunogenicity of BA.1 and BA.5 bivalent boosters.

Zhang et al. design a nanostructure which activates an adaptive martensitic transformation mechanism in a nuclear grade austenitic stainless steel, achieving extraordinary radiation resistance with non-degraded mechanical properties.

Trends in global H₂ sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

The nature of spin interactions and the field-induced quantum spin liquid phase in the Kitaev material α-RuCl₃ have been debated. Here, using a combination of many-body techniques, the authors derive an effective spin model that explains the majority of experimental findings and predicts a new quantum spin liquid phase in strong out-of-plane magnetic field.

A transverse Peierls transition can occur when transverse acoustic phonons couple with conducting p-orbital electrons. Here, the authors observe an incommensurate transverse Peierls transition and signatures of a chiral charge density wave in EuAl₄.

Magnons are elementary quasiparticles describing collective excitations of magnetic materials, however more complex quasiparticles can arise from attractive interactions between magnons. Here the authors report several types of magnetic excitations in a spin-1 magnet FeI2 and uncover new magnon decay paths.

A statistical method to quantify crystallographic textures in aluminum alloys under additive manufacturing conditions is introduced. Experiments and simulations reveal interfacial energy anisotropy dominates texture selection and grain competition.