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Showing 1–7 of 7 results
Advanced filters: Author: W. Peter Maksym Clear advanced filters

  • The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated approach and show that Cdk2/cyclin A-bound p27 samples lowly-populated conformations that dynamically anticipate the sequential steps of the signaling cascade.

    • Maksym Tsytlonok
    • Hugo Sanabria
    • Richard Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Genome-wide data from 400 individuals indicate that the initial spread of the Beaker archaeological complex between Iberia and central Europe was propelled by cultural diffusion, but that its spread into Britain involved a large-scale migration that permanently replaced about ninety per cent of the ancestry in the previously resident population.

    • Iñigo Olalde
    • Selina Brace
    • David Reich
    Research
    Nature
    Volume: 555, P: 190-196

  • An uncharacteristically long stellar disruption from a supermassive black hole has been unravelling over the last decade. Spectral information implies very efficient accretion but recent observations hint at a transition to a less extreme accretion mode.

    • Dacheng Lin
    • James Guillochon
    • Stephen D. J. Gwyn
    Research
    Nature Astronomy
    Volume: 1, P: 1-5