Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: WILLIAM E. BAKEWELL Clear advanced filters

  • Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid leukaemia.

    • Malgorzata Gozdecka
    • Monika Dudek
    • George S. Vassiliou
    ResearchOpen Access
    Nature
    Volume: 642, P: 431-441

  • Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

    • Calvin Law
    • Vanessa Sue Wacleche
    • Deepak A. Rao
    Research
    Nature
    Volume: 631, P: 857-866

  • Optogenetic activation of β2-adrenergic receptors (β2-AR) has been achieved, but not characterized in detail. Here, Siudaet al. show that light-controlled opto-β2AR mimics endogenous β2AR activity in vitro and in vivo, and develop novel, optically active, functionally selective receptors to bias β2AR intracellular signaling mechanisms.

    • Edward R. Siuda
    • Jordan G. McCall
    • Michael R. Bruchas
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Dietary restriction in rodents and non-human primates affects key nutrient-sensing signalling pathways to increase healthspan and lifespan. This Review discusses these geroprotective mechanisms and recent insights suggesting that dietary restriction results in similar molecular and metabolic changes in humans, contributing to the prevention of ageing-associated diseases.

    • Cara L. Green
    • Dudley W. Lamming
    • Luigi Fontana
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 56-73