Nature Search

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

The Zika viral protease NS2B-NS3 is a crucial target for antiviral drug development due to its role in processing viral polyproteins. Here, the authors utilize crystallographic fragment screening and deep mutational scanning to identify binding sites for resistance-resilient inhibitors.

Xiaomin Ni
R. Blake Richardson
Frank von Delft
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Cost-effectiveness of PCI guided by fractional flow reserve

In 2009, the FAME investigators reported that percutaneous coronary intervention guided by fractional flow reserve (FFR) could reduce the incidence of cardiovascular events when compared with angiographically guided PCI. The economic study conducted on the basis of FAME has now shown that an FFR-guided approach can also result in reduced costs.

Doralisa Morrone
William S. Weintraub
News & Views25 Feb 2011
Nature Reviews Cardiology

Volume: 8, P: 125-126
Somatic microsatellite mutations as molecular tumor clocks

Darryl Shibata
William Navidi
Lauri A. Aaltonen
Research01 Jun 1996
Nature Medicine

Volume: 2, P: 676-681
Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Pressure overload in the heart, such as from aortic stenosis, triggers early molecular changes before visible damage occurs. Here, the authors show that combining proteomics, transcriptomics, and genetic data reveals key drivers of heart failure, highlighting potential targets for treatment.

Brian R. Lindman
Andrew S. Perry
Sammy Elmariah
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-16
The evolutionary history of 2,658 cancers

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Moritz Gerstung
Clemency Jolly
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 122-128
The Molecular Weight of Glycogen

WILLIAM FEARON
Research22 Nov 1924
Nature

Volume: 114, P: 752
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

Shiv Srivastava
Zhiqiang Zou
Esther H. Chang
Research27 Dec 1990
Nature

Volume: 348, P: 747-749
Combined chemokine and cytokine gene transfer enhances antitumor immunity

Dagmar Dilloo
Kevin Bacon
Malcolm Brenner
Research01 Oct 1996
Nature Medicine

Volume: 2, P: 1090-1095
cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

Benton D. Tong
David E. Auer
Thomas F. Deuel
Research13 Aug 1987
Nature

Volume: 328, P: 619-621
Interaction between the retinoblastoma protein and the oncoprotein MDM2

Zhi-Xlong Xiao
Jiandong Chen
David M. Livingston
Research22 Jun 1995
Nature

Volume: 375, P: 694-698
Frequent loss of heterozygosity on chromosomes 7 and 9 in benign epithelial ovarian tumours

William J Roy Jr
Richard H Watson
Ian G Campbell
Research23 Oct 1997
Oncogene

Volume: 15, P: 2031-2035
The β-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus

Tom Glaser
William H. Lewis
D. E. Housman
Research26 Jun 1986
Nature

Volume: 321, P: 882-887
Exploring protein hotspots by optimized fragment pharmacophores

Fragment-based drug discovery employs screening of small polar compounds typically exhibiting low affinity towards protein targets. Here, the authors combine the use of protein-based binding pharmacophores with the theory of protein hotspots to develop a design protocol for fragment libraries, called SpotXplorer, and validate their approach on common and emerging drug targets.

Dávid Bajusz
Warren S. Wade
György M. Keserű
ResearchOpen Access27 May 2021
Nature Communications

Volume: 12, P: 1-10
Utility of High-Sensitivity and Conventional Troponin in Patients Undergoing Transcatheter Aortic Valve Replacement: Incremental Prognostic Value to B-type Natriuretic Peptide

Yukari Kobayashi
Juyong B. Kim
Francois Haddad
ResearchOpen Access17 Oct 2019
Scientific Reports

Volume: 9, P: 1-7
The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

Christine C Zhang
Jin-Ming Yang
William N Hait
Research01 Apr 1998
Oncogene

Volume: 16, P: 1617-1624
Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

Number of IL-9-expressing ILC2s are elevated in patients with inflammatory arthritis during remission, and these cells are critical in mice for the resolution of inflammatory arthritis via regulatory T cell induction. Delivery of DNA minicircles encoding IL-9 into inflamed joints ameliorates mouse experimental arthritis, suggesting possible therapeutic applications.

Simon Rauber
Markus Luber
Andreas Ramming
Research17 Jul 2017
Nature Medicine

Volume: 23, P: 938-944
Epigenetics and colorectal cancer

Colorectal cancer (CRC) results from an accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms them into adenocarcinomas. Over the past decade, major advances have been made in understanding cancer epigenetics, particularly regarding aberrant DNA methylation. Lao and Grady provide an overview of the role of epigenetics in CRC and discuss the clinical applications of these epigenetic alterations as biomarkers for early detection, diagnosis, prognostication and management of patients with CRC.

Victoria Valinluck Lao
William M. Grady
Reviews18 Oct 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 686-700
Antitumoral effect of a nonviral interleukin-2 gene therapy is enhanced by combination with 5-fluorouracil

Jeffrey S Bishop
Nikolyn M Thull
Federica Pericle
Research13 Sept 2000
Cancer Gene Therapy

Volume: 7, P: 1165-1171
Climate as a risk factor for armed conflict

Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.

Katharine J. Mach
Caroline M. Kraan
Nina von Uexkull
Research12 Jun 2019
Nature

Volume: 571, P: 193-197
Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets

Martyn Fyles
Karina-Doris Vihta
Thomas House
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-19
Signal transduction in mammary tumorigenesis: a transgenic perspective

David L Dankort
William J Muller
Research07 Mar 2000
Oncogene

Volume: 19, P: 1038-1044
Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings

Srdjan Sumarac
Jinyoung Youn
Luka Milosevic
ResearchOpen Access12 Sept 2024
npj Parkinson's Disease

Volume: 10, P: 1-11
Synovial tissue research: a state-of-the-art review

Advances in synovial tissue research have improved our understanding of inflammatory arthritides, particularly rheumatoid arthritis, and have identified potential biomarkers that could be used for diagnosis, disease stratification, and predicting disease course and treatment response.

Carl Orr
Elsa Vieira-Sousa
Douglas J. Veale
Reviews13 Jul 2017
Nature Reviews Rheumatology

Volume: 13, P: 463-475
Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation

Adil Bahar
John E Bicknell
William E Farrell
Research01 Dec 2003
Oncogene

Volume: 23, P: 936-944
COVID Border Accountability Project, a hand-coded global database of border closures introduced during 2020

Mary A. Shiraef
Cora Hirst
Mary Louise Mitsdarffer
ResearchOpen Access29 Sept 2021
Scientific Data

Volume: 8, P: 1-11

Search

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

Cost-effectiveness of PCI guided by fractional flow reserve

Somatic microsatellite mutations as molecular tumor clocks

Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

The evolutionary history of 2,658 cancers

The Molecular Weight of Glycogen

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

Combined chemokine and cytokine gene transfer enhances antitumor immunity

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

Interaction between the retinoblastoma protein and the oncoprotein MDM2

Frequent loss of heterozygosity on chromosomes 7 and 9 in benign epithelial ovarian tumours

The β-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus

Exploring protein hotspots by optimized fragment pharmacophores

Utility of High-Sensitivity and Conventional Troponin in Patients Undergoing Transcatheter Aortic Valve Replacement: Incremental Prognostic Value to B-type Natriuretic Peptide

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

Epigenetics and colorectal cancer

Antitumoral effect of a nonviral interleukin-2 gene therapy is enhanced by combination with 5-fluorouracil

Climate as a risk factor for armed conflict

Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets

Signal transduction in mammary tumorigenesis: a transgenic perspective

Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings

Synovial tissue research: a state-of-the-art review

Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation

COVID Border Accountability Project, a hand-coded global database of border closures introduced during 2020

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