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Showing 1–7 of 7 results
Advanced filters: Author: Walter Marcotti Clear advanced filters

  • Mechanisms underlying the initiation and modulation of the firing activity in the cochlea and its dynamics in vivo are not fully understood. Here, the authors investigate the origin and regulation of spontaneous Ca2+ signals in the hair cells, supporting cells and afferent fibre terminals in the developing cochlea from live mice.

    • Francesca De Faveri
    • Federico Ceriani
    • Walter Marcotti
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Johnson and colleagues investigate spiking activity in developing inner hair cells (IHCs), showing that apical IHCs fire spontaneous action potentials in a burst-like pattern, whereas basal IHCs fire randomly. The burst-like firing of apical IHCs depends on acetylcholine. Extracellular ATP affects the resting potential of IHCs by activating SK2 channels.

    • Stuart L Johnson
    • Tobias Eckrich
    • Walter Marcotti
    Research
    Nature Neuroscience
    Volume: 14, P: 711-717

  • Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.

    • Laura F. Corns
    • Stuart L. Johnson
    • Walter Marcotti
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Mammalian cochlea inner hair cells (IHCs) can code a continuous grading of sound intensities. This is because neurotransmitter release at mature sensory ribbon synapses is linearly dependent on calcium influx, which has the effect of broadening the cells' dynamic range. Immature IHC neurotransmitter release is quite different. Here, the authors show that a switch from syanptogamin I and II to synaptogamin IV underlies this developmental change.

    • Stuart L Johnson
    • Christoph Franz
    • Walter Marcotti
    Research
    Nature Neuroscience
    Volume: 13, P: 45-52

  • Ikzf2, which encodes the transcription factor Helios, is identified as a crucial regulator of gene expression in maturing cochlear outer hair cells, and overexpression of Ikzf2 in inner hair cells induces prestin expression and electromotility.

    • Lauren Chessum
    • Maggie S. Matern
    • Ronna Hertzano
    Research
    Nature
    Volume: 563, P: 696-700

  • Two types of human ES-cell-derived otic progenitors are shown to have the ability to differentiate in vitro into hair-cell-like cells and auditory neurons, and to engraft, differentiate and improve auditory-evoked response thresholds when transplanted into an auditory neuropathy model; this indicates that it may be possible to use cell-based therapeutic strategies to recover damaged sensory circuitry in deafness.

    • Wei Chen
    • Nopporn Jongkamonwiwat
    • Marcelo N. Rivolta
    Research
    Nature
    Volume: 490, P: 278-282