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Showing 1–6 of 6 results
Advanced filters: Author: Wanxia Li Tsai Clear advanced filters

  • Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes. Here the authors report a Phase 1 double-blind randomized trial that shows tofacitinib is safe and well tolerated in in patients with SLE.

    • Sarfaraz A. Hasni
    • Sarthak Gupta
    • Mariana J. Kaplan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

    • Cristina C. Clement
    • Angelo D’Alessandro
    • Laura Santambrogio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Ivona Aksentijevich and colleagues identify heterozygous loss-of-function mutations in TNFAIP3 (encoding A20) in six unrelated families with early-onset systemic inflammation. Affected individuals exhibit increased expression of NF-κB–mediated proinflammatory cytokines, consistent with the established role of A20 as a potent inhibitor of the NF-κB signaling pathway.

    • Qing Zhou
    • Hongying Wang
    • Ivona Aksentijevich
    Research
    Nature Genetics
    Volume: 48, P: 67-73