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Showing 1–5 of 5 results
Advanced filters: Author: Warren D Shlomchik Clear advanced filters

  • Graft-versus-host disease (GVHD) is an important clinical problem in haematopoietic stem-cell transplantation. Here, Warren Shlomchik describes advances in our understanding of this complex disease and the cells that are involved in its initiation and development, based on studies from experimental models.

    • Warren D. Shlomchik
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 340-352

  • In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.

    • Meng Zhou
    • Faruk Sacirbegovic
    • Warren D. Shlomchik
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • The cytokine TGF-β maintains the residency of cells of the immune system in barrier tissues. Kaplan and colleagues demonstrate that specific integrins expressed by epithelial cells activate latent TGF-β and that this is critical to maintain residency of cells of the immune system in the skin and gut.

    • Javed Mohammed
    • Lalit K Beura
    • Daniel H Kaplan
    Research
    Nature Immunology
    Volume: 17, P: 414-421

  • Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.

    • Quan Zhuang
    • Quan Liu
    • Adrian E. Morelli
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12