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Showing 1–5 of 5 results
Advanced filters: Author: Wataru Nishie Clear advanced filters
  • Collagen XVII directly binds to collagen IV at the basement membrane zone in both skin and oral mucosa. Mucous membrane pemphigoid autoantibodies targeting the C-terminus of collagen XVII hinder this binding and induce the detachment of basal cells in the oral mucosa. This mechanism leads to oral lesions that show less inflammation than the skin lesions show.

    • Mayumi Kamaguchi
    • Hiroaki Iwata
    • Hiroshi Shimizu
    Research
    Laboratory Investigation
    Volume: 99, P: 48-57
  • Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor that attenuates disease phenotypes in vivo.

    • Sho Hiroyasu
    • Matthew R. Zeglinski
    • David J. Granville
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Mammals exhibit epidermal patterning, as seen in mouse tail scales and human skin microtopography. In this article, the authors demonstrate that type XVII collagen (COL17), a niche for epidermal stem cells, modulate epidermal patterning in mice and humans. COL17 further prevents wound-induced epidermal deformation. This study paves the way for elucidating the role of the stem cell niche in tissue pattern formation.

    • Yunan Wang
    • Hiroyuki Kitahata
    • Ken Natsuga
    Research
    Laboratory Investigation
    Volume: 102, P: 581-588