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Advanced filters: Author: Weam S. Shahin Clear advanced filters

Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.

Weam S. Shahin
Shima O. Ebed
John F. Engelhardt
ResearchOpen Access27 Jan 2023
Nature Communications

Volume: 14, P: 1-13
Transgenic ferret models define pulmonary ionocyte diversity and function

Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.

Feng Yuan
Grace N. Gasser
John F. Engelhardt
ResearchOpen Access20 Sept 2023
Nature

Volume: 621, P: 857-867
Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus

Miao Yu
Xingshen Sun
John F. Engelhardt
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-13