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Showing 1–2 of 2 results
Advanced filters: Author: Wei-Hsuan Lan Clear advanced filters

  • Electro-osmosis in an anion-selective α-hemolysin nanopore is used to capture, unfold and transport polypeptides of over 1,200 residues, which allows the mapping of post-translational modifications in polypeptide chains by monitoring the ionic current at a single-molecule resolution.

    • Pablo Martin-Baniandres
    • Wei-Hsuan Lan
    • Hagan Bayley
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 18, P: 1335-1340

  • RAD51 and DMC1 recombinases catalyse high-fidelity and mismatch tolerant recombination, processes that are indispensable for the maintenance of genomic integrity. Here, the authors via cryo-EM, molecular dynamics simulation and functional analysis elucidate the structural difference between RAD51 and DMC1 with regard to mismatch tolerance.

    • Shih-Chi Luo
    • Hsin-Yi Yeh
    • Ming-Daw Tsai
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10