Neural mechanisms underlying flexibility in valence assignment are not fully understood. Here authors show that in C. elegans, attraction or repulsion to ethanol odor is controlled by a single sensory neuron, ASER. Optogenetic manipulation of its excitation state can switch the worm’s preference, revealing a simple neural logic for determining valence.
- Weikang Xue
- Yuanhua Chen
- Yanxun V. Yu
