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The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

Whether the female reproductive tract harbours distinct microbiomes beyond the vagina has been a matter of debate. Here, the authors show a subject-specific continuity in microbial communities at six sites along the female reproductive tract, indicative of a non-sterile environment.

Chen Chen
Xiaolei Song
Huijue Jia
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-11
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 ⁺ VSMCs adversely contribute to plaque progression and highlight their unexpected role in plaque stability by regulating the direction of VSMC trans-differentiation.

Ming Zhai
Shiyu Gong
Wenhui Peng
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-15
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.

Peipei Luan
Weixia Jian
Wenhui Peng
ResearchOpen Access28 Jun 2019
Nature Communications

Volume: 10, P: 1-16
The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai

Yanyun Gu
Tianhong Luo
Min Luo
Research01 Jul 2006
Journal of Human Genetics

Volume: 51, P: 605-610
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53

Shiyu Gong
Ming Zhai
Wenhui Peng
ResearchOpen Access05 Jan 2024
Cell Death & Differentiation

Volume: 31, P: 239-253

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The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai

TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53

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