The reason of mature tertiary lymphoid structures (mTLS) correlates with better prognosis and responses to immune checkpoint blockade (ICB) remains incompletely understood. By employing sequencing and spatial transcriptomics strategies, the authors show that mTLS are enriched with progenitor exhausted CD4+ T cells that promotes activation of T and B cells.
- Hao Li
- Meng-Jie Zhang
- Zhi-Jun Sun
