Nature Search

Activation of Raf-1 by 14-3-3 proteins

Wendy J. Fantl
Anthony J. Muslin
Lewis T. Williams
Research13 Oct 1994
Nature

Volume: 371, P: 612-614
Publisher Correction: High-resolution myogenic lineage mapping by single-cell mass cytometry

Ermelinda Porpiglia
Nikolay Samusik
Helen M. Blau
Amendments and Corrections05 Mar 2018
Nature Cell Biology

Volume: 20, P: 990
Integration of mechanistic immunological knowledge into a machine learning pipeline improves predictions

Recent advances have increased the dimensionality and complexity of immunological data. The authors developed a machine learning approach to incorporate prior immunological knowledge and applied it on clinical examples and a simulation study. The approach may be useful for high-dimensional datasets in clinical settings where the cohort size is limited.

Anthony Culos
Amy S. Tsai
Nima Aghaeepour
Research12 Oct 2020
Nature Machine Intelligence

Volume: 2, P: 619-628
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

Tian-Qiang Sun
Bingwei Lu
Lewis T. Williams
Research06 Jun 2001
Nature Cell Biology

Volume: 3, P: 628-636
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

Myeloid cells are critical in the pathology of inflammatory and degenerative brain diseases. The authors use single-cell mass cytometry (CyTOF) to reveal distinct characteristics in these cells in models of neural inflammation and degeneration.

Bahareh Ajami
Nikolay Samusik
Lawrence Steinman
Research05 Mar 2018
Nature Neuroscience

Volume: 21, P: 541-551
Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse

Mass cytometry of diagnostic biopsies from children with B cell precursor acute lymphoblastic leukemia identifies a signaling state that predicts relapse.

Zinaida Good
Jolanda Sarno
Kara L Davis
Research05 Mar 2018
Nature Medicine

Volume: 24, P: 474-483
High-resolution myogenic lineage mapping by single-cell mass cytometry

Porpiglia et al. use single-cell mass cytometry to analyse surface markers and key myogenic transcription factors of skeletal muscle stem cells during homeostasis and repair, and identify previously unrecognized myogenic progenitor cell populations.

Ermelinda Porpiglia
Nikolay Samusik
Helen M. Blau
Research17 Apr 2017
Nature Cell Biology

Volume: 19, P: 558-567
Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm

This protocol describes how to use mass-tag cell barcoding to label individual cell samples with unique combinatorial barcodes. The samples can then be pooled for processing and measurement on a mass cytometer.

Eli R Zunder
Rachel Finck
Garry P Nolan
Protocols22 Jan 2015
Nature Protocols

Volume: 10, P: 316-333
Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry

The immunoassay multiplexing capacity of single-cell mass cytometry relies on monoclonal antibodies labeled with stable heavy-metal isotopes. Nolan et al. describe procedures for conjugating monoclonal IgG antibodies with 48 heavy-metal isotopes.

Guojun Han
Matthew H. Spitzer
Garry P. Nolan
Protocols26 Sept 2018
Nature Protocols

Volume: 13, P: 2121-2148

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