The efficacy of radiotherapy is sometimes hindered by the hypoxic and immunosuppressive tumor microenvironment. Chen et al. develop an injectable hydrogel encapsulating IL-12/aCTLA-4 co-engineered red blood cells, thereby alleviating hypoxia-induced radioresistance and sequentially releasing aCTLA-4/IL-12 to relieve tumor immunosuppression.
- Yue Chen
- Qinyi Chen
- Wenpei Fan
