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Showing 1–4 of 4 results
Advanced filters: Author: Wesley F Zandberg Clear advanced filters

  • Characterization of the polysaccharide utilization loci from two Bacteroides species from the human gut microbiota define biochemical and structural features underlying the catabolism of a hybrid algal polysaccharide found in edible seaweed.

    • Craig S. Robb
    • Joanne K. Hobbs
    • Alisdair B. Boraston
    Research
    Nature Chemical Biology
    Volume: 18, P: 501-510

  • Understanding the reaction mechanism of OGT, responsible for O-GlcNAcylating various protein substrates, has been hampered by a lack of structural information. Snapshots of ternary complexes along the reaction coordinate now provide evidence for substrate participation in an electrophilic migration mechanism.

    • Michael B Lazarus
    • Jiaoyang Jiang
    • Suzanne Walker
    Research
    Nature Chemical Biology
    Volume: 8, P: 966-968

  • Feeding of modified carbohydrates has previously led to metabolic incorporation of these compounds into cellular glycans. Now the strategic use of a thiol analog that can be converted into an activated sugar but not incorporated into glycans provides a potent intracellular glycosyltransferase inhibitor.

    • Tracey M Gloster
    • Wesley F Zandberg
    • David J Vocadlo
    Research
    Nature Chemical Biology
    Volume: 7, P: 174-181

  • O-GlcNAcylation is a known post-translational modification, but analysis of nascent proteins now demonstrates that it also occurs during translation, preventing proteolytic degradation of modified proteins by blocking ubiquitination.

    • Yanping Zhu
    • Ta-Wei Liu
    • David J Vocadlo
    Research
    Nature Chemical Biology
    Volume: 11, P: 319-325