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Showing 1–3 of 3 results
Advanced filters: Author: Whitney Tamaki Clear advanced filters

  • Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation but also that its upregulation is associated with resistance to targeted therapies. This study highlights the complex and context-dependent role of APOBEC3B in lung cancer.

    • Deborah R. Caswell
    • Philippe Gui
    • Charles Swanton
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 60-73

  • Remaining drug-tolerant persistent (DTP) cancer cells limit the efficacy of targeted therapy in EGFR, ALK and KRAS mutant non-small cell lung cancer (NSCLC). Here, the authors show that focal adhesion kinase (FAK)-YAP signalling supports DTP cells promoting residual disease and targeting this pathway improved tumour response in NSCLC preclinical models.

    • Franziska Haderk
    • Yu-Ting Chou
    • Trever G. Bivona
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Single-cell combinatorial indexed cytometry sequencing (SCITO-seq) combines split-pool indexing and droplet-based single-cell sequencing for single-cell protein profiling.

    • Byungjin Hwang
    • David S. Lee
    • Chun Jimmie Ye
    Research
    Nature Methods
    Volume: 18, P: 903-911