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Showing 1–3 of 3 results
Advanced filters: Author: Wibke Schwarzer Clear advanced filters

  • Depletion of chromosome-associated cohesin leads to loss of topologically associating domains in interphase chromosomes, without affecting segregation into compartments, and instead, it unmasks a finer compartment structure that reflects local chromatin and transcriptional activity.

    • Wibke Schwarzer
    • Nezar Abdennur
    • Francois Spitz
    Research
    Nature
    Volume: 551, P: 51-56

  • A base-editing approach optimized to target the retina shows high editing rates in a mouse model of Stargardt disease, as well as in nonhuman primates and ex vivo human retinal explants, paving the way for potential clinical applications.

    • Alissa Muller
    • Jack Sullivan
    • Bence György
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 490-501

  • Genomic duplications in the SOX9 region are associated with human disease phenotypes; a study using human cells and mouse models reveals that the duplications can cause the formation of new higher-order chromatin structures called topologically associated domains (TADs) thereby resulting in changes in gene expression.

    • Martin Franke
    • Daniel M. Ibrahim
    • Stefan Mundlos
    Research
    Nature
    Volume: 538, P: 265-269