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Showing 1–6 of 6 results
Advanced filters: Author: Wiktor Szymanski Clear advanced filters

  • Avoiding the development of microbial antibiotic resistance is a major challenge. Now the incorporation of a photoswitchable group into quinolones has been used to create ‘smart’ antibiotics that can be activated with light. The subsequent loss of activity (within hours) should prevent the build-up of active antibiotics in the environment.

    • Willem A. Velema
    • Jan Pieter van der Berg
    • Ben L. Feringa
    Research
    Nature Chemistry
    Volume: 5, P: 924-928

  • The circadian clock is an internal mechanism that controls various physiological processes, such as the sleep-wake cycle, but its precise regulation is challenging. Here, the authors develop a visible light-responsive inhibitor of casein kinase I which controls the period and phase of cellular and tissue circadian rhythms in a reversible manner.

    • Dušan Kolarski
    • Carla Miró-Vinyals
    • Ben L. Feringa
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • While molecular photoswitches have proven useful in many fields, selective and reversible control over multiple switches is an unsolved challenge. Here, the authors report on a system consisting of two classes of photoswitches that can be addressed orthogonally and demonstrate the applicability in phase-transfer control.

    • Michael M. Lerch
    • Mickel J. Hansen
    • Ben L. Feringa
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • The design of photoswitches which operate in the visible light regime, show a large separation of absorption bands and are functional in various solvents is challenging. Here the authors report Iminothioindoxyls as visible-light operated photoswitches with a band separation of 100 nm.

    • Mark W. H. Hoorens
    • Miroslav Medved’
    • Wiktor Szymanski
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Substituted aspartic acids are highly valuable as tools for biological research and as chiral building blocks for pharmaceuticals. Here, engineering of the enzyme methylaspartate ammonia lyase to accept a large variety of substituted amines and fumarates and catalyse the asymmetric synthesis of aspartic acid derivatives is described.

    • Hans Raj
    • Wiktor Szymański
    • Gerrit J. Poelarends
    Research
    Nature Chemistry
    Volume: 4, P: 478-484

  • Photoclick reactions have found applications ranging from surface functionalization and polymer crosslinking to protein labelling and bioimaging, but they typically require near-UV and mid-UV light to proceed. This Review presents and discusses strategies and recent advances for long wavelength-driven photoclick reactions.

    • Youxin Fu
    • Nadja A. Simeth
    • Ben L. Feringa
    Reviews
    Nature Reviews Chemistry
    Volume: 8, P: 665-685