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A transatlantic joint lab model for interdisciplinary research

A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.

Angelique Hoelzemer
Wilfredo F. Garcia-Beltran
Comments & Opinion22 Sept 2025
Nature Microbiology

Volume: 10, P: 2356-2358
Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular signature of engraftment potential

Kim Vanuytsel
Carlos Villacorta-Martin
George J. Murphy
ResearchOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease.

Wilfredo F Garcia-Beltran
Angelique Hölzemer
Marcus Altfeld
Research25 Jul 2016
Nature Immunology

Volume: 17, P: 1067-1074
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors. Carrington and colleagues provide comprehensive analysis of classical HLA class I SP variants and show that these can determine CD94/NKG2–HLA-E engagement.

Zhansong Lin
Arman A. Bashirova
Mary Carrington
Research01 Jun 2023
Nature Immunology

Volume: 24, P: 1087-1097
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Of 12 serology assays tested, four detect antibodies in more than 80% of patients with COVID-19.

Jeffrey D. Whitman
Joseph Hiatt
Alexander Marson
Research27 Aug 2020
Nature Biotechnology

Volume: 38, P: 1174-1183
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Nir Hacohen, Bruce Walker, David Sabatini, Eric Lander and colleagues perform a CRISPR–Cas9-based screen for host factors that are required for HIV infection. They identify two known and three novel factors that are necessary for viral infection but that are not required for cell viability, making them potential targets for antiviral therapy.

Ryan J Park
Tim Wang
Bruce D Walker
Research19 Dec 2016
Nature Genetics

Volume: 49, P: 193-203
A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

NK cells recognize class I and stress-associated ligands. Altfeld and colleagues identify the NK cell receptor NKp44 as directly interacting with the class II HLA-DP in a partially peptide-dependent manner and with functional consequences for NK cell activity.

Annika Niehrs
Wilfredo F. Garcia-Beltran
Marcus Altfeld
Research29 Jul 2019
Nature Immunology

Volume: 20, P: 1129-1137
Peptide-specific engagement of the activating NK cell receptor KIR2DS1

Anaïs Chapel
Wilfredo F. Garcia-Beltran
Marcus Altfeld
ResearchOpen Access25 May 2017
Scientific Reports

Volume: 7, P: 1-12

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