Nature Search

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

Mutations in the NRF2-KEAP1 pathway is found to be related with therapeutic resistance and poor outcomes of non-small cell lung cancer (NSCLC). Here this group reports that cystine/glutamate antiporter system xc−, controlled by NRF2, can be non-invasively imaged by positron emission tomography thereby providing a sensitive and specific marker of NRF2 activation in advanced preclinical models of NSCLC.

Hannah E. Greenwood
Abigail R. Barber
Timothy H. Witney
ResearchOpen Access17 Dec 2024
Nature Communications

Volume: 15, P: 1-14
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.

Jing-Hui Tian
Nita Patel
Gale Smith
ResearchOpen Access14 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Cancer/testis antigens and urological malignancies

In this Review, Kulkarni and colleagues evaluate the available literature regarding the utility of cancer/testis antigens as biomarkers and therapeutic tools for patients with prostate, bladder, renal cell, and testicular germ cell tumours.

Prakash Kulkarni
Takumi Shiraishi
Robert H. Getzenberg
Reviews19 Jun 2012
Nature Reviews Urology

Volume: 9, P: 386-396
Epidemiology — identifying the causes and preventability of cancer?

In the 25 years since Doll and Peto published their groundbreaking report on the causes of cancers and strategies for prevention, there have been many additional epidemiological studies of cancer incidence. What do we now know about opportunities for cancer prevention?

Graham A. Colditz
Thomas A. Sellers
Edward Trapido
Reviews22 Dec 2005
Nature Reviews Cancer

Volume: 6, P: 75-83
A physical sciences network characterization of non-tumorigenic and metastatic cells

David B. Agus
Jenolyn F. Alexander
Pei-Hsun Wu
ResearchOpen Access26 Apr 2013
Scientific Reports

Volume: 3, P: 1-12
Enhancing the efficacy of cancer vaccines in urologic oncology: new directions

Cancer vaccines, which stimulate the host immune response to malignant disease, have generally failed to induce durable clinical responses in patients, partly owing to tumor-mediated suppression of the host immune system. Here, Kusmartsev and Vieweg explore ways of targeting these tumor-mediated changes to enhance the efficacy of vaccine therapy for urologic cancers.

Sergei Kusmartsev
Johannes Vieweg
Reviews08 Sept 2009
Nature Reviews Urology

Volume: 6, P: 540-549
Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium

Jessica L. Petrick
Charlotte E. Joslin
Lynn Rosenberg
Research21 Oct 2023
British Journal of Cancer

Volume: 129, P: 1956-1967
Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium

Heather M. Ochs-Balcom
Courtney Johnson
Elisa V. Bandera
Research22 Sept 2022
British Journal of Cancer

Volume: 127, P: 1983-1990

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