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Showing 1–3 of 3 results
Advanced filters: Author: William J. Haveman Clear advanced filters

  • The canonical role of messenger RNA (mRNA) is in protein coding and synthesis. But could mRNAs also have a role that is related to their ability to compete for microRNA binding? Here, the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 is investigated. The results suggest that pseudogenes have a biological function, in sequestering microRNAs and so affecting their regulation of gene expression.

    • Laura Poliseno
    • Leonardo Salmena
    • Pier Paolo Pandolfi
    Research
    Nature
    Volume: 465, P: 1033-1038

  • Pier Paolo Pandolfi and colleagues report the generation of mice that express 80% of normal levels of the PTEN tumor suppressor. The mice develop a spectrum of tumors, including breast tumors that retain two copies of Pten, suggesting that subtle changes in expression can predispose to tumorigenesis.

    • Andrea Alimonti
    • Arkaitz Carracedo
    • Pier Paolo Pandolfi
    Research
    Nature Genetics
    Volume: 42, P: 454-458