Nature Search

BRD4-mediated repression of p53 is a target for combination therapy in AML

MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.

Anne-Louise Latif
Ashley Newcombe
Peter D. Adams
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Suppression of Malignancy by Cell Fusion

HENRY HARRIS
O. J. MILLER
T. TACHIBANA
Research26 Jul 1969
Nature

Volume: 223, P: 363-368
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
U1 snRNA associates with TFIIH and regulates transcriptional initiation

Kon Yew Kwek
Shona Murphy
Alexandre Akoulitchev
Research21 Oct 2002
Nature Structural Biology

Volume: 9, P: 800-805
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Multi-modal profiling reveals major alterations in colonic B cells in patients with ulcerative colitis, including reduced clonal diversity of plasma cells, and suggests that circulating gut-homing plasmablasts could serve as a biomarker for disease activity.

Mathieu Uzzan
Jerome C. Martin
Saurabh Mehandru
Research21 Feb 2022
Nature Medicine

Volume: 28, P: 766-779
Unbiasing fermionic quantum Monte Carlo with a quantum computer

A hybrid quantum-classical algorithm for solving many-electron problems is developed, enabling the simulation, with the aid of 16 qubits on a quantum processor, of chemical systems with up to 120 orbitals.

William J. Huggins
Bryan A. O’Gorman
Joonho Lee
ResearchOpen Access16 Mar 2022
Nature

Volume: 603, P: 416-420
Quantum approximate optimization of non-planar graph problems on a planar superconducting processor

It is hoped that quantum computers may be faster than classical ones at solving optimization problems. Here the authors implement a quantum optimization algorithm over 23 qubits but find more limited performance when an optimization problem structure does not match the underlying hardware.

Matthew P. Harrigan
Kevin J. Sung
Ryan Babbush
Research04 Feb 2021
Nature Physics

Volume: 17, P: 332-336
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

Sebastijan Hobor
Maise Al Bakir
Charles Swanton
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-21
Peripheral T cell expansion predicts tumour infiltration and clinical response

Large-scale single-cell sequencing of RNA and T cell receptors in samples from patients with cancer shows clonotypic expansion of effector-like T cells not only in tumour tissue but also in normal adjacent tissues and peripheral blood, which associates with clinical response to cancer immunotherapy.

Thomas D. Wu
Shravan Madireddi
Jane L. Grogan
Research26 Feb 2020
Nature

Volume: 579, P: 274-278
Targeted breakage of a human chromosome mediated by cloned human telomeric DNA

Jane E. Itzhaki
Michael A. Barnett
Andrew C.G. Porter
News & Views01 Dec 1992
Nature Genetics

Volume: 2, P: 283-287
Transcription meets DNA repair at a PH domain

A recent study shows that the p62 subunit of the general transcription factor TFIIH contains a PH domain that interacts with a major component of the nucleotide excision repair (NER) machinery. The involvement of the PH domain in NER raises interesting questions regarding the dual role of TFIIH in transcription and DNA repair.

Kon Yew Kwek
William O'Gorman
Alexandre Akoulitchev
News & Views01 Jul 2004
Nature Structural & Molecular Biology

Volume: 11, P: 588-589
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
A clonal expression biomarker associates with lung cancer mortality

TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1540-1548
Mobile element insertions in rare diseases: a comparative benchmark and reanalysis of 60,000 exome samples

Robin Wijngaard
German Demidov
Christian Gilissen
ResearchOpen Access19 Oct 2023
European Journal of Human Genetics

Volume: 32, P: 200-208
Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study

Matthew J. Oberley
Sunil S. Raikar
Etan Orgel
Research14 Feb 2020
Leukemia

Volume: 34, P: 1741-1750
Correction: Mobile element insertions in rare diseases: a comparative benchmark and reanalysis of 60,000 exome samples

Robin Wijngaard
German Demidov
Christian Gilissen
Amendments and CorrectionsOpen Access16 Nov 2023
European Journal of Human Genetics

Volume: 32, P: 248

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