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Showing 1–50 of 285 results

Advanced filters: Author: William T. Pu Clear advanced filters

Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape

Noah Gamble
Alexandra Bradu
Andrew S. Koh
Amendments and Corrections16 May 2024
Nature Immunology

Volume: 25, P: 1123
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape

Koh et al. show that loci active in differentiated effector T cells are poised in early T precursors before the expression of T cell antigen receptors in a manner dependent on the chromatin remodeling complex mammalian SWItch/Sucrose Non-Fermentable and the PU.1–RUNX1 and BCL11B–RUNX1 complexes.

Noah Gamble
Alexandra Bradu
Andrew S. Koh
Research17 Apr 2024
Nature Immunology

Volume: 25, P: 860-872
Structure stability of (U, Pu) C and (U, Pu) N compositions

William A. Watson
Sophie Cooper
Robin W. Grimes
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-13
Tracing genetic diversity captures the molecular basis of misfolding disease

Pei et al. applied Gaussian process-based machine learning to capture dynamic spatial covariance relationships managed by proteostasis to mediate cooperative folding on a residue basis as a standard model for precision disease management.

Pei Zhao
Chao Wang
William E. Balch
ResearchOpen Access18 Apr 2024
Nature Communications

Volume: 15, P: 1-22
Molecular basis of symbiosis between Rhizobium and legumes

Christoph Freiberg
Rémy Fellay
Xavier Perret
Research22 May 1997
Nature

Volume: 387, P: 394-401
Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment

The effect of noncoding genetic variation on acute lymphoblastic leukemia treatment response is not fully understood. Here, the authors functionally evaluated variants associated with pharmacological traits and validate the role of rs1247117 in gene regulation impacting therapeutic response.

Kashi Raj Bhattarai
Robert J. Mobley
Daniel Savic
ResearchOpen Access01 May 2024
Nature Communications

Volume: 15, P: 1-14
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

Enhancer variants associated with red blood cell traits alter signaling transcription factor motifs, leading to changes in expression of genes that are upregulated during erythroid differentiation.

Avik Choudhuri
Eirini Trompouki
Leonard I. Zon
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1333-1345
PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

Brittany M. Curtiss
Jake VanCampen
Theodore P. Braun
Research19 May 2022
Leukemia

Volume: 36, P: 1781-1793
Effects of Insulin and Glucose Concentrations on Glucose Utilization in Fetal Sheep

William W Hay Jr.
Huei K Meznarich
Gary Zerbe
Research01 Apr 1988
Pediatric Research

Volume: 23, P: 381-387
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.

Suhasini Joshi
Erica DaGama Gomes
Gabriela Chiosis
ResearchOpen Access25 Nov 2021
Communications Biology

Volume: 4, P: 1-20
Quantification of actinide α-radiation damage in minerals and ceramics

Ian Farnan
Herman Cho
William J. Weber
Research11 Jan 2007
Nature

Volume: 445, P: 190-193
A global profile of replicative polymerase usage

Genome-wide DNA polymerase usage maps determined in fission yeast, using a new sequencing strategy based on ribonucleotide misincorporation, track the division of labor between replicative polymerases and reveal locations and efficiencies of replication origins.

Yasukazu Daigaku
Andrea Keszthelyi
Antony M Carr
Research09 Feb 2015
Nature Structural & Molecular Biology

Volume: 22, P: 192-198
Chemical Investigation of Hæmoglobin F from an Individual with Persistent Fœtal Hæmoglobin

W. A. SCHROEDER
PHILLIP STURGEON
WILLIAM R. BERGREN
Research24 Mar 1962
Nature

Volume: 193, P: 1161-1162
Thiol-Capped Gold Nanoparticles Swell-Encapsulated into Polyurethane as Powerful Antibacterial Surfaces Under Dark and Light Conditions

Thomas J. Macdonald
Ke Wu
Ivan P. Parkin
ResearchOpen Access16 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

The PU.1-related transcription factor Spi-C controls the development of a tissue macrophage subset in the spleen involved in the removal of red blood cells. Spi-C deficient mice fail to phagocytose trapped red blood cells.

Masako Kohyama
Wataru Ise
Kenneth M. Murphy
Research26 Nov 2008
Nature

Volume: 457, P: 318-321
Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts

Erwan Le Scolan
Françoise Wendling
Françoise Moreau-Gachelin
Research12 Sept 2001
Oncogene

Volume: 20, P: 5484-5492
Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage

Eomes is a critical transcription factor in trophectoderm development. Here, the authors uncovered the molecular basis of Eomes function in embryo implantation and expansion of this extra-embryonic lineage.

Alexandra Maria Bisia
Maria-Eleni Xypolita
Ita Costello
ResearchOpen Access31 May 2025
Nature Communications

Volume: 16, P: 1-13
Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation

Nathan J. VanDusen
Julianna Y. Lee
William T. Pu
Amendments and CorrectionsOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1
Suppression of Gluconeogenesis and Endogenous Glucose Production by Exogenous Insulin Administration in the Newborn Lamb

John B Susa
Richard M Cowett
Robert Schwartz
Research01 May 1979
Pediatric Research

Volume: 13, P: 594-598
Endogenous Glucose Production during Constant Glucose Infusion in the Newborn Lamb

Richard M Cowett
John B Susa
Robert Schwartz
Research01 Aug 1978
Pediatric Research

Volume: 12, P: 853-857
Endogenous Posthepatic Insulin Secretion and Metabolic Clearance Rates in the Neonatal Lamb

Richard M Cowett
John B Susa
William Oh
Research01 Dec 1980
Pediatric Research

Volume: 14, P: 1391-1394
Primary brain calcification: an international study reporting novel variants and associated phenotypes

Eliana Marisa Ramos
Miryam Carecchio
Gaël Nicolas
Research28 Jun 2018
European Journal of Human Genetics

Volume: 26, P: 1462-1477
Evaluation of Insulin Sensitivity in Obese Offspring of Diabetic Rats by Hyperinsulinemic-Euglycemic Clamp Technique

Nancy L Gelardi
Chung-Ja M Cha
William Oh
Research01 Jul 1991
Pediatric Research

Volume: 30, P: 40-44
Effects of Guinea-pig Serum on the Walker 256 Carcinosarcoma

WILLIAM C. DOLOWY
ROBERT SCHREK
ERIC BROWN
Research15 Jun 1968
Nature

Volume: 218, P: 1028-1031
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

Diane Pennica
William E. Holmes
Desire Collen
Research20 Jan 1983
Nature

Volume: 301, P: 214-221
Cooperative tandem binding of met repressor of Escherichia coli

Simon E. V. Phillips
Iain Manfield
Peter G. Stockley
Research26 Oct 1989
Nature

Volume: 341, P: 711-715
Markovian Models of Dialogic Time Patterns

J. JAFFE
S. FELDSTEIN
L. CASSOTTA
Research07 Oct 1967
Nature

Volume: 216, P: 93-94
Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation

William R. Swindell
Andrew Johnston
Johann E. Gudjonsson
ResearchOpen Access05 Feb 2013
Scientific Reports

Volume: 3, P: 1-13
Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs

Azacitidine (AZA) response in myelodysplastic neoplasms is unpredictable. Here, the authors show in a phase 2 trial that while global methylation changes did not differ by response, baseline and initial CpG methylation differences in HSPCs predicted AZA response.

Julie A. I. Thoms
Feng Yan
John E. Pimanda
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-20
CA AND P REGULATING HORMONES DURING THE 1ST YR OF LIFE: A LONGITUDINAL PROSPECTIVE STUDY

Jean J Steichen
Reginald C Tsang
William Brazerol
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 214
GASTRIC MOTILITY AND GI BLOOD FLOW: EFFECTS OF HYPOXEMIA IN THE NEWBORN PIGLET

Joanne S Szabo
Barbara S Stonestreet
William Oh
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 214
THE EFFECT OF NONNUTRITIVE AND NUTRITIVE SUCK ON GASTRIC EMPTYING IN PREMATURE INFANTS

Joanne S Szabo
A Craig Hillemeier
William Oh
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 214
Synthesis of Superheavy Elements in the r-Process

DAVID N. SCHRAMM
WILLIAM A. FOWLER
Research14 May 1971
Nature

Volume: 231, P: 103-106
β-Lactoglobulins

K. BELL
H. A. McKENZIE
Research26 Dec 1964
Nature

Volume: 204, P: 1275-1279
Predicting cell type-specific epigenomic profiles accounting for distal genetic effects

Enformer Celltyping is a genomic deep learning model that predicts epigenetic signals in unseen cell types using distal DNA interactions and chromatin accessibility data. Here, authors show it generalises across cell types and evaluate its use for genetic variant effect predictions and in complex traits.

Alan E. Murphy
William Beardall
Nathan G. Skene
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Phototherapy for Neonatal Jaundice: in Vivo Clearance of Bilirubin Photoproducts

John F Ennever
Isabella Knox
William T Speck
Research01 Feb 1985
Pediatric Research

Volume: 19, P: 205-208
Lower Cretaceous sediment from the East Antarctic continental shelf

Eugene W. Domack
William W. Fairchild
John B. Anderson
Research16 Oct 1980
Nature

Volume: 287, P: 625-626
Ultraviolet spectrum of quasi–stellar object 3C273

Arthur F. Davidsen
George F. Hartig
William G. Fastie
Research15 Sept 1977
Nature

Volume: 269, P: 203-206
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment

Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while simultaneously preventing iPS cell-derived mesodermal stem cells from differentiating into alternative lineages.

Danyang Chen
Xiaonuo Fan
William T. Pu
Research10 Jun 2025
Nature Cardiovascular Research

Volume: 4, P: 689-709
Urinary Arginine Vasopressin: Pattern of Excretion in the Neonatal Period

Suvipa Wiriyathian
Charles R Rosenfeld
William D Engle
Research01 Feb 1986
Pediatric Research

Volume: 20, P: 103-108
Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner
William Haseltine
Flossie Wong-Staal
Research24 Jan 1985
Nature

Volume: 313, P: 277-284
High-throughput chromatin accessibility profiling at single-cell resolution

Single-cell chromatin accessibility is a promising means to identify regulatory programs in mixtures of cells. Here the authors describe µ-ATAC-seq, a low-cost method that can generate thousands of accessibility profiles per day.

Anja Mezger
Sandy Klemm
William Greenleaf
ResearchOpen Access07 Sept 2018
Nature Communications

Volume: 9, P: 1-6
An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells

Different activation patterns of Akt kinase direct downstream signaling outcomes. Here, the authors run phosphoproteomics on optogenetically-activated Akt1 to characterize the phosphorylation circuits induced by different intensities, durations, and patterns of stimulation.

Wenping Zhou
Wenxue Li
Yansheng Liu
ResearchOpen Access26 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Degradation of Elements

WILLIAM RAMSAY
Research31 Mar 1904
Nature

Volume: 69, P: 512
Structural Homology of Human, Bovine, and Porcine Milk Lactoferrins: Evidence for Shared Antigenic Determinants

Scott J Magnuson
Joseph F Henry
William T Hutchens
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 176-181
Feedback improves compliance of pressure relief activities in wheelchair users with spinal cord injury

Michèle Hubli
Roland Zemp
William R. Taylor
ResearchOpen Access21 Jul 2020
Spinal Cord

Volume: 59, P: 175-184
Advances and perspectives in fiber-based electronic devices for next-generation soft systems

Hwajoong Kim
Daehyeon Kim
Jaehong Lee
ReviewsOpen Access09 Aug 2025
npj Flexible Electronics

Volume: 9, P: 1-39
Photosensitised electron transport across phospholipid vesicle walls

WILLIAM E. FORD
JOHN W. OTVOS
MELVIN CALVIN
Research03 Aug 1978
Nature

Volume: 274, P: 507-508
Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo

Computational methods are used to predict which peptides or antigens are able to bind to MHC in order to activate T cell receptors in neoantigen-directed immunotherapies. Here the authors present an accurate transformer-based method to consider not only the peptide and MHC but also the source antigenic protein to predict peptides which bind to MHC molecules.

William John Thrift
Nicolas W. Lounsbury
Suchit Jhunjhunwala
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Virtual terminator nucleotides for next-generation DNA sequencing

Nucleotide analogs modified with a free 3′ hydroxyl, maintaining the interactions at the polymerase active site, and a cleavable linker, attaching a fluorescent dye and an inhibitor, are efficient at reading homopolymer runs in a single-molecule sequencing reaction.

Jayson Bowers
Judith Mitchell
John F Thompson
Research20 Jul 2009
Nature Methods

Volume: 6, P: 593-595

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