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Showing 1–14 of 14 results

Advanced filters: Author: Winfried Edelmann Clear advanced filters

Correction: Corrigendum: (CAG)_n-hairpin DNA binds to Msh2–Msh3 and changes properties of mismatch recognition

Barbara A L Owen
Zungyoon Yang
Cynthia T McMurray
Amendments and Corrections01 Sept 2005
Nature Structural & Molecular Biology

Volume: 12, P: 824
DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication

Resolution of G4s has been suggested to be required for efficient DNA replication. Here, the authors show that the nuclease DNA2 and the DNA repair complex MutSα (MSH2-MSH6) are required to remove G4 stabilized by environmental compounds to allow efficient telomere replication.

Anthony Fernandez
Tingting Zhou
Binghui Shen
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Mouse models for colorectal cancer

Joerg Heyer
Kan Yang
Raju Kucherlapati
Research20 Sept 1999
Oncogene

Volume: 18, P: 5325-5333
Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6^−/− small intestinal epithelium

Sean C Mark
Linda E Sandercock
Frank R Jirik
Research09 Oct 2002
Oncogene

Volume: 21, P: 7126-7130
Tumor-associated Apc mutations in Mlh1^−/−Apc^1638N mice reveal a mutational signature of Mlh1 deficiency

Mari Kuraguchi
Winfried Edelmann
Anthony MC Brown
Research23 Nov 2000
Oncogene

Volume: 19, P: 5755-5763
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

Yuxun Wang
Christopher D Putnam
Winfried Edelmann
Research19 Jun 2005
Nature Genetics

Volume: 37, P: 750-755
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

Winfried Edelmann
Paula E. Cohen
Raju Kucherlapati
Research01 Jan 1999
Nature Genetics

Volume: 21, P: 123-127
Cardiac defects and renal failure in mice with targeted mutations in Pkd2

Guanqing Wu
Glen S. Markowitz
Stefan Somlo
Research01 Jan 2000
Nature Genetics

Volume: 24, P: 75-78
H1 histones control the epigenetic landscape by local chromatin compaction

Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and histone methylation.

Michael A. Willcockson
Sean E. Healton
Arthur I. Skoultchi
Research09 Dec 2020
Nature

Volume: 589, P: 293-298
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice

Philip D Bardwell
Caroline J Woo
Matthew D Scharff
Research11 Jan 2004
Nature Immunology

Volume: 5, P: 224-229
(CAG)_n-hairpin DNA binds to Msh2–Msh3 and changes properties of mismatch recognition

Barbara A L Owen
Zungyoon Yang
Cynthia T McMurray
Research17 Jul 2005
Nature Structural & Molecular Biology

Volume: 12, P: 663-670
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

Minimal reduction of PU.1 in mice is sufficient to elicit a preleukemic state that, when combined with a DNA mismatch repair defect, results in progression to myelodysplastic syndrome and acute myeloid leukemia.

Britta Will
Thomas O Vogler
Ulrich Steidl
Research07 Sept 2015
Nature Medicine

Volume: 21, P: 1172-1181
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

New xenograft models of colorectal cancer exhibit metastasis to the liver, use immunocompetent mice and show improved resistance to chemotherapy.

Huanhuan Joyce Chen
Jian Sun
Steven M Lipkin
Research25 May 2015
Nature Biotechnology

Volume: 33, P: 656-660
The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair

J M M van Oers
Y Edwards
W Edelmann
Research09 Sept 2013
Oncogene

Volume: 33, P: 3939-3946