Nature Search

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

Amy K. Y. Fu
Wing-Yu Fu
Nancy Y. Ip
Research01 Apr 2001
Nature Neuroscience

Volume: 4, P: 374-381
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

Wing-Yu Fu
Yu Chen
Nancy Y Ip
Research03 Dec 2006
Nature Neuroscience

Volume: 10, P: 67-76
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

Shuo Gu
Wing-Yu Fu
Nancy Y. Ip
ResearchOpen Access09 May 2018
Scientific Reports

Volume: 8, P: 1-7
APC^Cdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

Homeostatic plasticity can be induced by increasing neuronal activity and is mediated, in part, by AMPAR endocytosis. Here Fu et al. describe the involvement of EphA4 in synaptic scaling via ubiquitin-dependent degradation of AMPAR.

Amy K Y Fu
Kwok-Wang Hung
Nancy Y Ip
Research26 Dec 2010
Nature Neuroscience

Volume: 14, P: 181-189
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

Phosphorylation of synaptic substrates by Cdk5 plays an essential role in synapse development. Here Zhang et al. reveal that S-nitrosylation of the activator of Cdk5, p35, by nitric oxide results in its degradation and reduced Cdk5 activity, leading to alterations in synaptic strength.

Peng Zhang
Wing-Yu Fu
Nancy Y. Ip
ResearchOpen Access27 Oct 2015
Nature Communications

Volume: 6, P: 1-11
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

This study reveals a novel function of the Rho GTPase-activating protein called α2-chimerin in cortical development, where acute knockdown of α2-chimerin caused neuronal migration deficit and cortical circuit malformation in the developing mouse brain. This developmental defect was also associated with an impairment of circuit development causing epileptic discharges in adult animals.

Jacque P K Ip
Lei Shi
Nancy Y Ip
Research04 Dec 2011
Nature Neuroscience

Volume: 15, P: 39-47
Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect

Wei-Wei Chen
Wing-Yu Fu
Nancy Y. Ip
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection

Fanny CF Ip
Wing-Yu Fu
Nancy Y Ip
ResearchOpen Access04 Feb 2015
Neuropsychopharmacology

Volume: 40, P: 1877-1887
p39-associated Cdk5 activity regulates dendritic morphogenesis

Li Ouyang
Yu Chen
Nancy Y. Ip
ResearchOpen Access30 Oct 2020
Scientific Reports

Volume: 10, P: 1-16
Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model

Jackie K. Y. Lau
Min Tian
Nancy Y. Ip
ResearchOpen Access23 Feb 2021
Scientific Reports

Volume: 11, P: 1-15

Search

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

APC^Cdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect

Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection

p39-associated Cdk5 activity regulates dendritic morphogenesis

Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model

Search

Quick links

Search

Filter By:

Search

Quick links