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Showing 1–4 of 4 results
Advanced filters: Author: Wolfgang Bermel Clear advanced filters

  • Correlating aromatic carbons attached to fluorine with meta-position hydrogens in fluorine-labelled phenylalanines can yield two-dimensional correlations with narrow linewidths in large proteins. Adapting phenylalanine-tRNA synthetase increases the incorporation rate, while expanding the genetic code enables site-specific incorporation of fluorinated phenylalanine. The resulting HCF-transverse relaxation-optimized spectroscopy can illuminate protein dynamics and drive multiplexed drug discovery campaigns.

    • Andras Boeszoermenyi
    • Denitsa L. Radeva
    • Haribabu Arthanari
    Research
    Nature Chemistry
    Volume: 17, P: 835-846

  • The structure and dynamics of large proteins and complexes can be studied by methyl-NMR but resonance assignment is still challenging. Here, the authors present a NMR method that leverages optimal control pulse design to unambiguously distinguish between Leu and Val using a simple 2D HMQC experiment and they apply it to several proteins including Cas9, interleukin, and human translation initiation factor eIF4a.

    • Soumya P. Behera
    • Abhinav Dubey
    • Haribabu Arthanari
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • In vivo NMR spectroscopy of whole, living multicellular organisms involves maintaining live organisms within an NMR spectrometer and analysing their metabolic profiles in real time. In this Primer, Lysak and colleagues describe experimental approaches for in vivo NMR, including solution-state and magic-angle spinning NMR.

    • Daniel H. Lysak
    • Katelyn Downey
    • Andre J. Simpson
    Reviews
    Nature Reviews Methods Primers
    Volume: 3, P: 1-21