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Showing 1–8 of 8 results
Advanced filters: Author: Wolfgang Bildl Clear advanced filters

  • GABAB receptors are the G-protein-coupled receptors for γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain. Here, functional proteomics is used to show that GABAB receptors in the brain are complexes of GABAB1, GABAB2 and members of a subfamily of KCTD proteins. The KCTD proteins increase the potency of agonists and markedly alter the G-protein signalling of the receptors, suggesting that they determine the pharmacology and kinetics of the receptor response.

    • Jochen Schwenk
    • Michaela Metz
    • Bernhard Bettler
    Research
    Nature
    Volume: 465, P: 231-235

  • During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe SARS-CoV-2 infection.

    • Jakob Ankerhold
    • Sebastian Giese
    • Valeria Falcone
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • An analysis of MitCOM—a comprehensive resource for the identification, organization and interaction of mitochondrial machineries and pathways in yeast—identifies a constitutive pathway for the removal of preproteins.

    • Uwe Schulte
    • Fabian den Brave
    • Thomas Becker
    ResearchOpen Access
    Nature
    Volume: 614, P: 153-159

  • The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads to severe filtration defects with proteinuria.

    • Maciej K. Kocylowski
    • Hande Aypek
    • Florian Grahammer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression

    • Margarita C. Dinamarca
    • Adi Raveh
    • Bernhard Bettler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual disability and epilepsy in three families.

    • Aline Brechet
    • Rebecca Buchert
    • Bernd Fakler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • GABAB receptors are the most abundant inhibitory G protein–coupled receptors in the mammalian brain. Using high-resolution proteomics, the authors show that native GABAB receptors are macromolecular complexes with previously unknown complexity in subunit composition. This molecular diversity in structure and assembly encodes the diversity of GABAB physiology in the CNS.

    • Jochen Schwenk
    • Enrique Pérez-Garci
    • Bernd Fakler
    Research
    Nature Neuroscience
    Volume: 19, P: 233-242