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Publisher Correction: IRE1α modulates ER and mitochondria crosstalk

Roland Malli
Wolfgang F. Graier
Amendments and Corrections13 Sept 2019
Nature Cell Biology

Volume: 21, P: 1300
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1

Genetic and biochemical evidence reveals a functional interaction between mitochondrial proteins TMBIM5 and MICU1.

Li Zhang
Benjamin Gottschalk
Axel Methner
ResearchOpen Access19 Sept 2025
Communications Biology

Volume: 8, P: 1-13
Retraction Note: Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways

Andreas Yiallouris
Ioannis Patrikios
Anastasis Stephanou
Amendments and CorrectionsOpen Access20 Sept 2022
Cell Death & Disease

Volume: 13, P: 1
MICU1 controls cristae junction and spatially anchors mitochondrial Ca²⁺ uniporter complex

Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca²⁺ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.

Benjamin Gottschalk
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Aug 2019
Nature Communications

Volume: 10, P: 1-17
Erratum: Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca²⁺ uniport

Michael Trenker
Roland Malli
Wolfgang F. Graier
Amendments and Corrections01 Nov 2008
Nature Cell Biology

Volume: 10, P: 1371
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca²⁺ uptake in immortalized cells

MICU1 is a regulatory subunit of mitochondrial Ca²⁺ channels that shields mitochondria from Ca²⁺ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca²⁺ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca²⁺uptake activity.

Corina T. Madreiter-Sokolowski
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Sept 2016
Nature Communications

Volume: 7, P: 1-13
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca²⁺ uniport

Michael Trenker
Roland Malli
Wolfgang F. Graier
Research11 Mar 2007
Nature Cell Biology

Volume: 9, P: 445-452
Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics

Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al. develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells.

Emrah Eroglu
Benjamin Gottschalk
Roland Malli
ResearchOpen Access04 Feb 2016
Nature Communications

Volume: 7, P: 1-11
IRE1α modulates ER and mitochondria crosstalk

IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca²⁺ channel InsP₃Rs and facilitates the transfer of Ca²⁺ from the ER into mitochondria, thus driving cellular metabolism.

Roland Malli
Wolfgang F. Graier
News & Views20 May 2019
Nature Cell Biology

Volume: 21, P: 667-668
UCP2/3 — likely to be fundamental for mitochondrial Ca²⁺ uniport

Michael Trenker
Ismene Fertschai
Wolfgang F. Graier
Correspondence01 Nov 2008
Nature Cell Biology

Volume: 10, P: 1237-1240
Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy

Benjamin Gottschalk
Zhanat Koshenov
Wolfgang F. Graier
ResearchOpen Access26 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

K⁺ plays an important role in physiology and disease, but the lack of high specificity K⁺ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K⁺ concentration in body fluids, cells and specific organelles.

Helmut Bischof
Markus Rehberg
Roland Malli
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Yes (again) to local NO

A pair of fluorescent indicator-tagged DNA-duplex scaffolds permit assessments of nitric oxide (NO) production on cell surfaces and in intracellular networks. The application of these nanoprobes indicates formations of local NO signals that might conserve cancer cell integrity.

Emrah Eroglu
Thomas Michel
Roland Malli
News & Views22 May 2020
Nature Chemical Biology

Volume: 16, P: 606-607
Selective targeting of genes regulated by zinc finger proteins in endometriosis and endometrioid adenocarcinoma by zinc niflumato complex with neocuproine

Ivana Špaková
Lukáš Smolko
Miroslava Rabajdová
ResearchOpen Access24 Mar 2025
Scientific Reports

Volume: 15, P: 1-19
Citrin mediated metabolic rewiring in response to altered basal subcellular Ca²⁺ homeostasis

Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca²⁺ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca²⁺ dynamics can reprogram cellular and mitochondrial metabolism.

Zhanat Koshenov
Furkan E. Oflaz
Wolfgang F. Graier
ResearchOpen Access20 Jan 2022
Communications Biology

Volume: 5, P: 1-15
MICU1 controls spatial membrane potential gradients and guides Ca²⁺ fluxes within mitochondrial substructures

Within mitochondrial substructures, MICU1 is shown to mediate Ca²⁺ control over spatial membrane potential gradients (SMPGs), with alterations in SMPGs following Ca²⁺ binding to MICU1 resulting in spatial cristae depolarization.

Benjamin Gottschalk
Zhanat Koshenov
Wolfgang F. Graier
ResearchOpen Access01 Jul 2022
Communications Biology

Volume: 5, P: 1-13
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca²⁺

Markus Waldeck-Weiermair
Roland Malli
Wolfgang F. Graier
ResearchOpen Access22 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
The Role of PGE₂ in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk

Thomas Bärnthaler
Jovana Maric
Akos Heinemann
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-17
Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for lipotoxicity

Patrick Rockenfeller
Martin Smolnig
Frank Madeo
ResearchOpen Access23 May 2018
Cell Death & Differentiation

Volume: 25, P: 767-783
RETRACTED ARTICLE: Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways

Andreas Yiallouris
Ioannis Patrikios
Anastasis Stephanou
ResearchOpen Access09 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-13
Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells

Ivana Špaková
Miroslava Rabajdová
Mária Mareková
ResearchOpen Access14 May 2021
Scientific Reports

Volume: 11, P: 1-14

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