The authors report the conditional deletion of the alpha and beta forms of glycogen synthase kinase 3 (GSK-3) in mouse neural progenitors. This deletion is associated with dysregulations in β-catenin, Sonic Hedgehog, Notch and fibroblast growth factor signaling pathways and leads to markedly increased proliferation of neural progenitors.
- Woo-Yang Kim
- Xinshuo Wang
- William D Snider
