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Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.

Wook-Bin Lee
Ji-Seon Kang
Young-Joon Kim
ResearchOpen Access18 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules

Taeil Kim
Joonsun Yoon
Young-Joon Kim
Research09 Jan 2005
Nature Immunology

Volume: 6, P: 211-218
Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis

Wook-Bin Lee
Ji-Jing Yan
Young-Joon Kim
ResearchOpen Access23 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn–SIRPα–SHP1 complex

Quanri Zhang
Wook-Bin Lee
Young-Joon Kim
ResearchOpen Access05 Feb 2018
Experimental & Molecular Medicine

Volume: 50, P: e439
β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

Won Kyu Kim
Yujin Kwon
Hoguen Kim
ResearchOpen Access05 Dec 2019
Scientific Reports

Volume: 9, P: 1-15

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