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Advanced filters: Author: Xavier Gómez-Santacana Clear advanced filters

  • Alloswitch-1 is a photoswitchable modulator for mGlu5, and it is the first photoswitchable allosteric GPCR modulator. It was generated by adding the azobenzene Ar-N=N-Ar scaffold into an existing positive allosteric modulator of the receptor.

    • Silvia Pittolo
    • Xavier Gómez-Santacana
    • Pau Gorostiza
    Research
    Nature Chemical Biology
    Volume: 10, P: 813-815

  • G protein-coupled receptors (GPCR) are a complex superfamily of membrane proteins that have a key role in regulating various physiological processes, however, the specific labelling of native GPCRs to monitor their function remains challenging. Here, the authors report a modular click ligand-directed approach to covalently attach fluorescent dyes to endogenous dopamine D1 receptors in live cells.

    • Xavier Gómez-Santacana
    • Marin Boutonnet
    • Amadeu Llebaria
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-12