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Advanced filters: Author: Xavier Gaume Clear advanced filters

A molecular roadmap for the emergence of early-embryonic-like cells in culture

Rare cells resembling the 2-cell-stage embryo (2 C) arise in embryonic stem cell cultures. By performing single-cell analyses and an siRNA screen, the authors identify the intermediate cellular states and epigenetic regulators that underpin the transition to a 2C-like state.

Diego Rodriguez-Terrones
Xavier Gaume
Maria-Elena Torres-Padilla
Research18 Dec 2017
Nature Genetics

Volume: 50, P: 106-119
Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Netrin-1, via precise Neo1/Unc5B stoichiometry, promotes naive pluripotency, embryonic stem cell self-renewal in combination with leukaemia inhibitory factor, and the formation of the mouse epiblast in vivo.

Aurélia Huyghe
Giacomo Furlan
Fabrice Lavial
Research30 Mar 2020
Nature Cell Biology

Volume: 22, P: 389-400
Integrated analysis of mRNA and miRNA expression in HeLa cells expressing low levels of Nucleolin

Sanjeev Kumar
Elizabhet Cruz Gomez
Philippe Bouvet
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-17