James Brugarolas and colleagues identify recurrent BAP1 mutations in clear cell renal cell carcinoma (ccRCC). They show that BAP1 binds to HCF-1 and suppresses cell proliferation, and they find that BAP1 loss is associated with high tumor grade.
- Samuel Peña-Llopis
- Silvia Vega-Rubín-de-Celis
- James Brugarolas