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PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow

Programmed death ligand 1 (PD-L1) suppresses host immunity during infection and microbial sepsis. Here, the authors show that PD-L1 does this by regulating the secretion of CXCL1 and CXCL2 to control neutrophil mobilization during Candida albicans infection.

Yao Yu
Rong-Rong Wang
Xin-Ming Jia
ResearchOpen Access11 Nov 2022
Nature Communications

Volume: 13, P: 1-16

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PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow

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