Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis, leading to the production of IL-10 and suppression of CD8 T cells.
- Fang-Zhu Ouyang
- Rui-Qi Wu
- Dong-Ming Kuang