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Showing 1–6 of 6 results
Advanced filters: Author: Xianpeng Ge Clear advanced filters
  • Grain number per panicle (GNP) is a yield-determining trait of rice. Here, the authors identify a GSK3-like kinase-encoding gene GNP2 and a bZIP transcription factor-encoding gene GNP5, demonstrating their synergistic regulation of GNP and showing that specific allele combinations of these genes enhance rice yield in field conditions.

    • Qianfeng Hu
    • Zhikun Zhao
    • Zhanying Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3). Here the authors provide evidence that the two mammalian E1 enzymes, Uba1 and Uba6, exert biologically distinct functions.

    • Xianpeng Liu
    • Bo Zhao
    • Hiroaki Kiyokawa
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12
  • Cdc13 forms a complex with Stn1-Ten1 that caps budding yeast telomeres; Cdc13 also recruits the telomerase complex. Indeed, Cdk1 phosphorylates Cdc13 and this favors the Cdc13- Est1p, at the expense of Cdc13 association with Stn1, which inhibits telomerase action at telomeres. Now a second, independent mechanism to control Cdc13-Stn1 interaction is revealed: sumoylation of Cdc13 promotes its interaction with Stn1 and prevents telomerase activity.

    • Lisa E Hang
    • Xianpeng Liu
    • Xiaolan Zhao
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 920-926
  • E3 ubiquitin ligases regulate biological functions by ubiquitinating defined substrate proteins but overlapping specificities complicate the identification of E3-substrate relationships. Here, the authors construct an orthogonal UB transfer cascade and identify specific substrates of the E3 enzyme E6AP.

    • Yiyang Wang
    • Xianpeng Liu
    • Jun Yin
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14
  • Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.

    • Jung-Min Kim
    • Yeon-Suk Yang
    • Jae-Hyuck Shim
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17