On rare occasions, some multiple myeloma patients develop pure red cell aplasia (PRCA) following combination therapy for multiple myeloma. Here the authors characterise bone marrow cells from PRCA patients by single cell sequencing showing hyperactive CD8+ T cells, impaired erythropoiesis, increase of MHC-I proteins and antigen presentation associated genes in erythroid cells.
- Qi Hu
- Yang Liu
- Hsiang-Ying Lee